A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis

A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis

Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS). Notably, in addition to its well-known mode of action as an S1P modulator, accumulating evidence suggests that FTY720 induces apoptosis in variou...

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Bibliographic Details
Main Authors: Kanako Hagihara, Kanako Kinoshita, Kouki Ishida, Shihomi Hojo, Yoshinori Kameoka, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiura
Format: Article
Language:English
Published: Shared Science Publishers OG 2017-11-01
Series:Microbial Cell
Subjects:
FTY720
ROS
chemical genomics
fission yeast
mechanism of cell death
Online Access:http://microbialcell.com/researcharticles/a-genome-wide-screen-for-fty720-sensitive-mutants-reveals-genes-required-for-ros-homeostasis/

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http://microbialcell.com/researcharticles/a-genome-wide-screen-for-fty720-sensitive-mutants-reveals-genes-required-for-ros-homeostasis/

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