Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates

Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates

Abstract Background 6-Bromo-7-[11C]methylpurine ([11C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated protein 1 (MRP1) transport activity in different tissues. Previously reported radiosyntheses of [11C]BMP afforded a mixture of 7- and 9-[11C]m...

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Bibliographic Details
Main Authors: Severin Mairinger, Matthias Jackwerth, Ondřej Soukup, Matthias Blaickner, Clemens Decristoforo, Lukas Nics, Jens Pahnke, Marcus Hacker, Markus Zeitlinger, Oliver Langer
Format: Article
Language:English
Published: SpringerOpen 2024-04-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
6-Bromo-7-[11C]methylpurine
Investigational medicinal product dossier
Multidrug resistance-associated protein 1
PET
Regioselective N‑alkylation
Online Access:https://doi.org/10.1186/s41181-024-00265-z

Internet

https://doi.org/10.1186/s41181-024-00265-z

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