Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment

Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment

Cisplatin, a chemotherapeutic agent, can cause nephrotoxic and ototoxic injuries. Using a mouse model of repeated low dose cisplatin (RLDC), we compared the kidneys of cisplatin- and vehicle-treated mice on days 3 (early injury phase) and 35 (late injury/recovery phase) after the final treatment. RN...

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Bibliographic Details
Main Authors: Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Tracy Murray Stewart, Jackson R. Foley, Ashley Nwafor, Robert A. Casero, Manoocher Soleimani
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
cisplatin
nephrotoxicity
chronic kidney injury
fibrosis
polyamine
polyamine catabolism
Online Access:https://www.mdpi.com/2227-9059/12/3/640

Internet

https://www.mdpi.com/2227-9059/12/3/640

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