Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials

Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials

Abstract Background The HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles in hematopoiesis and leukemogenesis. Methods We established HOXA9-inducible human embryonic stem cells (HOXA9/...

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Bibliographic Details
Main Authors: Jiahui Zeng, Danying Yi, Wencui Sun, Yuanlin Liu, Jing Chang, Lijiao Zhu, Yonggang Zhang, Xu Pan, Yong Dong, Ya Zhou, Mowen Lai, Guohui Bian, Qiongxiu Zhou, Jiaxin Liu, Bo Chen, Feng Ma
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:Cell Regeneration
Subjects:
Hematopoiesis
Differentiation of hematopoietic lineages
HOXA9
Mesoderm
Human embryonic stem cells (hESCs)
Tet-on
Online Access:https://doi.org/10.1186/s13619-020-00066-0

Internet

https://doi.org/10.1186/s13619-020-00066-0

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