Discovery of a chalcone derivative as an anti-fibrotic agent targeting transforming growth factor-β1 signaling: Potential therapy of renal fibrosis

Discovery of a chalcone derivative as an anti-fibrotic agent targeting transforming growth factor-β1 signaling: Potential therapy of renal fibrosis

As a final common pathway of renal injuries, renal fibrosis leads to chronic kidney disease (CKD). Currently, there is no safe and effective therapy to prevent the progression of renal fibrosis to CKD. Inhibition of transforming growth factor-β1 (TGF-β1) pathway is proposed as one of the most promis...

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Bibliographic Details
Main Authors: Wanangkan Poolsri, Rattikarn Noitem, Promsuk Jutabha, Manasanan Raveesunthornkiat, Ade Danova, Warinthorn Chavasiri, Chatchai Muanprasat
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
RPTEC cells
Transforming growth factor-β1
Chalcone derivatives
Kidney fibrosis
UUO mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008892

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http://www.sciencedirect.com/science/article/pii/S0753332223008892

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