Targeting STAT6 to mitigate sepsis-induced muscle atrophy and weakness: Modulation of mitochondrial dysfunction, ferroptosis, and CHI3L1-Mediated satellite cell loss

Targeting STAT6 to mitigate sepsis-induced muscle atrophy and weakness: Modulation of mitochondrial dysfunction, ferroptosis, and CHI3L1-Mediated satellite cell loss

Sepsis-induced muscle weakness is a debilitating consequence of prolonged critical illness, often associated with a poor prognosis. While recent research has shown that STAT6 functions as an inhibitor of myogenesis, its role in sepsis-induced muscle weakness remains unclear. In this study, we hypoth...

Full description

Bibliographic Details
Main Authors: Zhiyong Sheng, Zhihong Yu, Meng Wang, Rui Zhou, Shenjian Chen, Xin Yu, Fuxing Li
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Sepsis-induced muscle atrophy
STAT6
Mitochondrial dysfunction
Ferroptosis
CHI3L1
Satellite cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001899

Internet

http://www.sciencedirect.com/science/article/pii/S2405580823001899

Similar Items