The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence

The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence

Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. We hypothesised that senescent osteoarthriti...

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Bibliographic Details
Main Authors: Susanne N. Wijesinghe, James Anderson, Thomas J. Brown, Dominika E. Nanus, Bas Housmans, Jonathan A. Green, Matthias Hackl, Katie K. Choi, Kenton P. Arkill, Tim Welting, Victoria James, Simon W. Jones, Mandy J. Peffers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
miRNA
tRNA
extracellular vescicles
senescence
synovial fibroblast
osteoarthiritis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.971621/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.971621/full

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