ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells

ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells

Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autopha...

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Bibliographic Details
Main Authors: Lv Ying, Xiao Sijie, Ouyang Shuhui, Peng Zhengliang, Wu Li, Tang Ziqing, Zhang Weizheng, Cao Renxian, Yang Jing
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
secretagogin
autophagic flux
apoptosis
lipotoxicity
β-cells
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022186

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022186

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