Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Orexins peptides exert a prominent role in arousal-related processes including stress responding, by activating orexin-1 (OX1R) and orexin-2 (OX2R) receptors located widely throughout the brain. Stress or orexin administration stimulates hyperarousal, adrenocorticotropic hormone (ACTH) and corticost...

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Bibliographic Details
Main Authors: Sujin Yun, Michelle Wennerholm, Jonathan E. Shelton, Pascal Bonaventure, Michael A. Letavic, Brock T. Shireman, Timothy W. Lovenberg, Christine Dugovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
orexin-1
orexin-2 receptor antagonist
ACTH
sleep
mice
Online Access:http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00083/full

Internet

http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00083/full

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