Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR

Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR

Tudor interacting repair regulator (TIRR) is a negative regulator of 53BP1 in DNA damage repair processes. Here the authors give mechanistic insights into how TIRR mediates suppression by solving the crystal structure of TIRR bound to the 53BP1 tandem Tudor domain (TTD).

Bibliographic Details
Main Authors: Jiaxu Wang, Zenglin Yuan, Yaqi Cui, Rong Xie, Guang Yang, Muzaffer A. Kassab, Mengxi Wang, Yinliang Ma, Chen Wu, Xiaochun Yu, Xiuhua Liu
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05174-9

Internet

https://doi.org/10.1038/s41467-018-05174-9

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