EGFRvIII Promotes the Proneural–Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis

EGFRvIII Promotes the Proneural–Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis

(1) Background: Glioblastoma multiforme (GBM) is the most common and malignant intracranial tumor in adults. At present, temozolomide (TMZ) is recognized as the preferred chemotherapeutic drug for GBM, but some patients have low sensitivity to TMZ or chemotherapy resistance to TMZ. Our previous stud...

Full description

Bibliographic Details
Main Authors: Zhong-Fang Shi, Guan-Zhang Li, You Zhai, Chang-Qing Pan, Di Wang, Ming-Chen Yu, Chi Liu, Wei Zhang, Xiao-Guang Yu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Genes
Subjects:
glioblastoma
EGFRvIII
ALDH1A3
NF-κB
proneural–mesenchymal transition
temozolomide
Online Access:https://www.mdpi.com/2073-4425/14/3/651

Internet

https://www.mdpi.com/2073-4425/14/3/651

Similar Items