B Cells Are Required to Generate Optimal Anti-Melanoma Immunity in Response to Checkpoint Blockade

B Cells Are Required to Generate Optimal Anti-Melanoma Immunity in Response to Checkpoint Blockade

Immunotherapies such as checkpoint blockade therapies are known to enhance anti-melanoma CD8+ T cell immunity, but only a fraction of patients treated with these therapies achieve durable immune response and disease control. It may be that CD8+ T cells need help from other immune cells to generate e...

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Bibliographic Details
Main Authors: Shubhra Singh, Jason Roszik, Neeraj Saini, Vipul Kumar Singh, Karishma Bavisi, Zhiqiang Wang, Long T. Vien, Zixi Yang, Suprateek Kundu, Richard E. Davis, Laura Bover, Adi Diab, Sattva S. Neelapu, Willem W. Overwijk, Kunal Rai, Manisha Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
knockout (KO)
programmed death-ligand 1 (PD-L1)
cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
the Cancer Genome Atlas melanoma (TCGA)
immunotherapy
Blymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.794684/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.794684/full

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