SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization

SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization

Abstract Sustained activation of signal transducer and activator of transcription 3 (STAT3) is a critical contributor in tumorigenesis and chemoresistance, thus making it an attractive cancer therapeutic target. Here, SH2 domain‐containing adapter protein F (SHF) is identified as a tumor suppressor...

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Bibliographic Details
Main Authors: Jingjing Wang, Zixuan Huang, Li Ji, Cheng Chen, Quan Wan, Yu Xin, Zhening Pu, Koukou Li, Jiantong Jiao, Ying Yin, Yaling Hu, Lingli Gong, Rui Zhang, Xusheng Yang, Xiangming Fang, Mei Wang, Bo Zhang, Junfei Shao, Jian Zou
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Advanced Science
Subjects:
dimerization
DNA methylation
DNA methyltransferase 1
glioblastoma
SH2 domain‐containing adapter protein F
signal transducer and activator of transcription 3
Online Access:https://doi.org/10.1002/advs.202200169

Internet

https://doi.org/10.1002/advs.202200169

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