Identification of the first antagonist peptide that inhibits biological effects of interleukin-15

Identification of the first antagonist peptide that inhibits biological effects of interleukin-15

Interleukin-15 (IL-15) is a pro-inflammatory cytokine that is expressed in several autoimmune and inflammatory diseases. We have identified the 36-45 sequence KVTAMKCFLL on human IL-15 that is recognized by a soluble form of recombinant hIL-15Ra-Fc fusion protein. This sequence synthesized as a 10 a...

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Bibliographic Details
Main Authors: Alicia Santos, Osvaldo Reyes, Ania Cabrales, Yunier Rodríguez, Haydee Geronimo, Hilda E Garay, Celia A Arrieta, Miriam Ojeda, Ana C Machado, José Suarez, Julio A Ancisar, Mariela Vázquez, Gerardo Guillén, Araceli Chico, Miguel Estévez, Alexey Llopiz, Jesús Noda, Aniel Sánchez, Lorenzo Silengo, Fiorella Altruda, Silvio Perea
Format: Article
Language:English
Published: Elfos Scientiae
Series:Biotecnología Aplicada
Subjects:
antagonist
cytokine
il-15
peptide
alpha receptor
Online Access:http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000400008&lng=en&tlng=en

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http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000400008&lng=en&tlng=en

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