Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway

Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway

Background: Curcumin ameliorates bone loss by inhibiting osteoclastogenesis. Curcumin inhibits RANKL-promoted autophagy in osteoclast precursors (OCPs), which mediates its anti-osteoclastogenic effect. But the role of RANKL signaling in curcumin-regulated OCP autophagy is unknown. This study aimed t...

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Bibliographic Details
Main Authors: Dianshan Ke, Haoying Xu, Junyong Han, Hanhao Dai, Xinwen Wang, Jun Luo, Yunlong Yu, Jie Xu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedical Journal
Subjects:
Curcumin
Osteoclast
RANKL
Autophagy
BCL2
Beclin1
Online Access:http://www.sciencedirect.com/science/article/pii/S2319417023000422

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http://www.sciencedirect.com/science/article/pii/S2319417023000422

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