Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement fa...

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Bibliographic Details
Main Authors: Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Mario R. Romano, Antonio Inforzato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
age-related macular degeneration
retinal pigmented epithelium
vitreous humor
complement system
alternative pathway
pentraxins
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.591908/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.591908/full

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