Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.

Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.

The use of synthetic long peptides (SLP) has been proven to be a promising approach to induce adaptive immune responses in vaccination strategies. Here, we analyzed whether the efficiency to activate cytotoxic T cells by SLP-based vaccinations can be increased by conjugating SLPs to mannose residues...

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Bibliographic Details
Main Authors: Judith Rauen, Christoph Kreer, Arlette Paillard, Suzanne van Duikeren, Willemien E Benckhuijsen, Marcel G Camps, A Rob P M Valentijn, Ferry Ossendorp, Jan W Drijfhout, Ramon Arens, Sven Burgdorf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138033?pdf=render

Internet

http://europepmc.org/articles/PMC4138033?pdf=render

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