Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases
Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress response to maintain cellular homeostasis. Identifying...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/2/518 |
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| author | Zahra Mohtashami Mithalesh Kumar Singh Farid Thomaz Neto Nasim Salimiaghdam Hossein Hasanpour M. Cristina Kenney |
| author_facet | Zahra Mohtashami Mithalesh Kumar Singh Farid Thomaz Neto Nasim Salimiaghdam Hossein Hasanpour M. Cristina Kenney |
| author_sort | Zahra Mohtashami |
| collection | DOAJ |
| description | Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress response to maintain cellular homeostasis. Identifying MOTS-c specific binding partners may aid in deciphering the complex web of mitochondrial and nuclear-encoded signals. Mitochondrial damage and dysfunction have been linked to aging and the accelerated cell death associated with many types of retinal degenerations. Furthermore, research on MOTS-c ability to revive oxidatively stressed RPE cells has revealed a significant protective role for the molecule. Evidence suggests that senescent cells play a role in the development of age-related retinal disorders. This review examines the links between MOTS-c, mitochondria, and age-related diseases of the retina. Moreover, the untapped potential of MOTS-c as a treatment for glaucoma, diabetic retinopathy, and age-related macular degeneration is reviewed. |
| first_indexed | 2024-03-11T09:14:21Z |
| format | Article |
| id | doaj.art-c4b4ac9fb261441bbd4b8979fe494946 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T09:14:21Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c4b4ac9fb261441bbd4b8979fe4949462023-11-16T18:49:23ZengMDPI AGAntioxidants2076-39212023-02-0112251810.3390/antiox12020518Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal DiseasesZahra Mohtashami0Mithalesh Kumar Singh1Farid Thomaz Neto2Nasim Salimiaghdam3Hossein Hasanpour4M. Cristina Kenney5Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USAMitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress response to maintain cellular homeostasis. Identifying MOTS-c specific binding partners may aid in deciphering the complex web of mitochondrial and nuclear-encoded signals. Mitochondrial damage and dysfunction have been linked to aging and the accelerated cell death associated with many types of retinal degenerations. Furthermore, research on MOTS-c ability to revive oxidatively stressed RPE cells has revealed a significant protective role for the molecule. Evidence suggests that senescent cells play a role in the development of age-related retinal disorders. This review examines the links between MOTS-c, mitochondria, and age-related diseases of the retina. Moreover, the untapped potential of MOTS-c as a treatment for glaucoma, diabetic retinopathy, and age-related macular degeneration is reviewed.https://www.mdpi.com/2076-3921/12/2/518MOTS-cmitochondrial dysfunctionglaucomadiabetic retinopathyage-related macular degeneration |
| spellingShingle | Zahra Mohtashami Mithalesh Kumar Singh Farid Thomaz Neto Nasim Salimiaghdam Hossein Hasanpour M. Cristina Kenney Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases Antioxidants MOTS-c mitochondrial dysfunction glaucoma diabetic retinopathy age-related macular degeneration |
| title | Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases |
| title_full | Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases |
| title_fullStr | Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases |
| title_full_unstemmed | Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases |
| title_short | Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases |
| title_sort | mitochondrial open reading frame of the 12s rrna type c potential therapeutic candidate in retinal diseases |
| topic | MOTS-c mitochondrial dysfunction glaucoma diabetic retinopathy age-related macular degeneration |
| url | https://www.mdpi.com/2076-3921/12/2/518 |
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