Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy

Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy

Knowledge of clinically targetable tumor antigens is becoming vital for broader design and utility of therapeutic cancer vaccines. This information is obtained reliably by directly interrogating the MHC-I presented peptide ligands, the immunopeptidome, with state-of-the-art mass spectrometry. Our ma...

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Bibliographic Details
Main Authors: Karita Peltonen, Sara Feola, Husen M. Umer, Jacopo Chiaro, Georgios Mermelekas, Erkko Ylösmäki, Sari Pesonen, Rui M. M. Branca, Janne Lehtiö, Vincenzo Cerullo
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
tumor antigen
endogenous retrovirus
cancer vaccine
immunotherapy
immunopeptidome
ligandome
Online Access:https://www.mdpi.com/2072-6694/13/14/3408

Internet

https://www.mdpi.com/2072-6694/13/14/3408

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