SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis

SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis

Abstract Background Inflammation is undoubtedly a hallmark of cancer development. Its maintenance within tumors and the consequences on disease aggressiveness are insufficiently understood. Methods Data of 27 tumor entities (about 5000 samples) were downloaded from the TCGA and GEO databases. Multi-...

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Bibliographic Details
Main Authors: Abdel Jelil Njouendou, Tibor Szarvas, Arnol Auvaker Zebaze Tiofack, Rovaldo Nguims Kenfack, Pamela Derliche Tonouo, Sidonie Noa Ananga, Esther H. M. Dina Bell, Gustave Simo, Jörg D. Hoheisel, Jens T. Siveke, Smiths S. Lueong
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Cancer
Subjects:
Tumor aggressiveness
Somatic copy number alterations
SOX2
IL6
FOSL2
Inflammation
Online Access:https://doi.org/10.1186/s12943-023-01734-w

Internet

https://doi.org/10.1186/s12943-023-01734-w

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