Selectively Modified Lactose and <em>N</em>-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands

Selectively Modified Lactose and <em>N</em>-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands

Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in inflammatory diseases. Lactose ((β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose, Lac) and <i>N</i>-Acetyllactosamine (2-acetamido-2-...

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Bibliographic Details
Main Authors: Shuay Abdullayev, Priyanka Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
galectin
lactoside
isothermal titration calorimetry (ITC)
X-ray
Online Access:https://www.mdpi.com/1422-0067/24/4/3718

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https://www.mdpi.com/1422-0067/24/4/3718

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