Effect of NAT2, GSTM1 and CYP2E1 genetic polymorphisms on plasma concentration of isoniazid and its metabolites in patients with tuberculosis, and the assessment of exposure-response relationships

Effect of NAT2, GSTM1 and CYP2E1 genetic polymorphisms on plasma concentration of isoniazid and its metabolites in patients with tuberculosis, and the assessment of exposure-response relationships

Objectives: Isoniazid is a key drug in the chemotherapy of tuberculosis (TB), however, interindividual variability in pharmacokinetic parameters and drug plasma levels may affect drug responses including drug induced hepatotoxicity. The current study investigated the relationships between isoniazid...

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Bibliographic Details
Main Authors: Viktorija Ulanova, Agnija Kivrane, Anda Viksna, Leonora Pahirko, Lauma Freimane, Darja Sadovska, Iveta Ozere, Andra Cirule, Eduards Sevostjanovs, Solveiga Grinberga, Dace Bandere, Renate Ranka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
NAT2
GSTM1
CYP2E1
pharmacogenomics
isoniazid
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1332752/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1332752/full

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