Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension

Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension

Activation of the renin angiotensin system plays a pivotal role in the regulation of blood pressure, which is mainly attributed to the formation of angiotensin-II (Ang II). The actions of Ang II are mediated through binding to the Ang-II type 1 receptor (AT1R) which leads to increased blood pressure...

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Bibliographic Details
Main Authors: Laale F. Alawi, Sanjeev Dhakal, Sana E. Emberesh, Harshal Sawant, Anhar Hosawi, Unmesha Thanekar, Nadja Grobe, Khalid M. Elased
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
ACE2 (angiotensin converting Enzyme-2)
neprilysin (NEP)
hypertension
renin angiotensin aldestron system
chronic kidney
urinary bio markers
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.602985/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.602985/full

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