Cardiolipin occupancy profiles of YidC paralogs reveal the significance of respective TM2 helix residues in determining paralog-specific phenotypes

Cardiolipin occupancy profiles of YidC paralogs reveal the significance of respective TM2 helix residues in determining paralog-specific phenotypes

YidC belongs to an evolutionarily conserved family of insertases, YidC/Oxa1/Alb3, in bacteria, mitochondria, and chloroplasts, respectively. Unlike Gram-negative bacteria, Gram-positives including Streptococcus mutans harbor two paralogs of YidC. The mechanism for paralog-specific phenotypes of bact...

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Bibliographic Details
Main Authors: Surabhi Mishra, Evan J. van Aalst, Benjamin J. Wylie, L. Jeannine Brady
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Streptococcus mutans
YidC
cardiolipin
molecular dynamics
paralog
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1264454/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1264454/full

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