Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signalling

Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signalling

Abstract X‐linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro‐inflammatory signalling downstream of the nucleotide‐binding oligomerization domain containing (NOD)‐1 and ‐2 pattern recognition receptors. Mutations in XIAP cause X‐linked lymphoproliferative syndrome type‐2 (...

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Bibliographic Details
Main Authors: Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker‐Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand, Mads Gyrd‐Hansen
Format: Article
Language:English
Published: Springer Nature 2013-07-01
Series:EMBO Molecular Medicine
Subjects:
BIR2
NOD2
Smac mimetic compounds
XIAP
XLP2
Online Access:https://doi.org/10.1002/emmm.201303090

Internet

https://doi.org/10.1002/emmm.201303090

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