Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant

Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant

Summary: Epilepsy and neurodevelopmental disorders can arise from pathogenic variants of KCNQ (Kv7) channels. A patient with developmental and epileptic encephalopathy exhibited an in-frame deletion of histidine 260 on Kv7.2. Coexpression of Kv7.2 mutant (mut) subunits with Kv7.3 invoked a decrease...

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Bibliographic Details
Main Authors: Xiaoqin Zhan, Chris Drummond-Main, Dylan Greening, Jinjing Yao, S.W.R. Chen, J.P. Appendino, P. Y. Billie Au, Ray W. Turner
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Health sciences
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013645

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http://www.sciencedirect.com/science/article/pii/S2589004222013645

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