Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function

Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function

Abstract Research suggests that ischemic glycolysis improves myocardial tolerance to anoxia and low-flow ischemia. The rate of glycolysis during ischemia reflects the severity of the injury caused by ischemia and subsequent functional recovery following reperfusion. Histone H2AK119 ubiquitination (H...

Full description

Bibliographic Details
Main Authors: Pilong Shi, Jiawei Wu, Minghui Li, Yonggang Cao, Jiabi Wu, Ping Ren, Kai Liu, Jiajun Zhou, Yuetong Sha, Qianhui Zhang, Hongli Sun
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01762-x

Internet

https://doi.org/10.1038/s41420-023-01762-x

Similar Items