The K<sup>+</sup>-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms

The K<sup>+</sup>-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms

Eukarya pyruvate kinases possess glutamate at position 117 (numbering of rabbit muscle enzyme), whereas bacteria have either glutamate or lysine. Those with E117 are K<sup>+</sup>-dependent, whereas those with K117 are K<sup>+</sup>-independent. In a phylogenetic tree, 80% of...

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Bibliographic Details
Main Authors: Leticia Ramírez-Silva, Gloria Hernández-Alcántara, Carlos Guerrero-Mendiola, Martin González-Andrade, Adela Rodríguez-Romero, Annia Rodríguez-Hernández, Alan Lugo-Munguía, Paul A. Gómez-Coronado, Cristina Rodríguez-Méndez, Alicia Vega-Segura
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
pyruvate kinase
enzyme purification
enzyme kinetics
crystal structure
molecular dynamics
circular dichroism
Online Access:https://www.mdpi.com/1422-0067/23/3/1347

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https://www.mdpi.com/1422-0067/23/3/1347

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