Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration

Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration

Aims: Cardiac dysfunction can be a fatal complication during severe sepsis. The migration of neutrophils is significantly impaired during severe sepsis. We sought to determine the role of trimetazidine (TMZ) in regulation of neutrophil migration to the heart in a mouse model of sepsis and endotoxemi...

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Bibliographic Details
Main Authors: Jing Chen, Bei Wang, Jinsheng Lai, Zachary Braunstein, Mengying He, Guoran Ruan, Zhongwei Yin, Jin Wang, Katherine Cianflone, Qin Ning, Chen Chen, Dao Wen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
pyroptosis
trimetazidine
septic cardiac dysfunction
neutrophil
AMPK-Nrf2-CXCR2 axis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02015/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02015/full

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