Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature

With the evolving COVID-19 pandemic, increasing concerns about invasive fungal infections have been reported particularly with the use of potent immunosuppressant medications to treat the immunological storms in patients with severe COVID-19 illnesses. Trichosporon asahii (T. asahii) is an emerging...

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Main Authors: Gawahir A. Ali, Ahmed Husain, Husam Salah, Wael Goravey
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:IDCases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214250921002006
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author Gawahir A. Ali
Ahmed Husain
Husam Salah
Wael Goravey
author_facet Gawahir A. Ali
Ahmed Husain
Husam Salah
Wael Goravey
author_sort Gawahir A. Ali
collection DOAJ
description With the evolving COVID-19 pandemic, increasing concerns about invasive fungal infections have been reported particularly with the use of potent immunosuppressant medications to treat the immunological storms in patients with severe COVID-19 illnesses. Trichosporon asahii (T. asahii) is an emerging highly resistant pathogen with considerable mortality particularly in critically ill patients and immunocompromised individuals. We describe a case of a 58-year-old patient who developed T. asahii fungemia after using immunosuppressant agents for his severe COVID-19 related cytokines release syndrome. Pseudohyphae, arthroconidia, and lateral blastoconidia were seen in the stain, and later confirmed to be T. asahii. Voriconazole successfully treated this multi-drug-resistant fungal infection. The clinical presentation, assessment, and management are reviewed to raise awareness of the circumstances leading to coinfection with this emerging resistant yeast.
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spelling doaj.art-c4d23b2d945c417aba71b0c4061fe40b2022-12-21T21:35:00ZengElsevierIDCases2214-25092021-01-0125e01244Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literatureGawahir A. Ali0Ahmed Husain1Husam Salah2Wael Goravey3Department of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Doha, QatarDepartment of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Doha, QatarDepartment of Laboratory Medicine and Pathology, HMC, Doha, QatarDepartment of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Doha, Qatar; Corresponding author at: Infectious Diseases Department, Hamad Medical Corporation, Doha, Qatar.With the evolving COVID-19 pandemic, increasing concerns about invasive fungal infections have been reported particularly with the use of potent immunosuppressant medications to treat the immunological storms in patients with severe COVID-19 illnesses. Trichosporon asahii (T. asahii) is an emerging highly resistant pathogen with considerable mortality particularly in critically ill patients and immunocompromised individuals. We describe a case of a 58-year-old patient who developed T. asahii fungemia after using immunosuppressant agents for his severe COVID-19 related cytokines release syndrome. Pseudohyphae, arthroconidia, and lateral blastoconidia were seen in the stain, and later confirmed to be T. asahii. Voriconazole successfully treated this multi-drug-resistant fungal infection. The clinical presentation, assessment, and management are reviewed to raise awareness of the circumstances leading to coinfection with this emerging resistant yeast.http://www.sciencedirect.com/science/article/pii/S2214250921002006COVID-19Trichosporon asahiiFungemiaVoriconazoleCentral venous catheters
spellingShingle Gawahir A. Ali
Ahmed Husain
Husam Salah
Wael Goravey
Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
IDCases
COVID-19
Trichosporon asahii
Fungemia
Voriconazole
Central venous catheters
title Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
title_full Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
title_fullStr Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
title_full_unstemmed Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
title_short Trichosporon asahii fungemia and COVID-19 co-infection: An emerging fungal pathogen; case report and review of the literature
title_sort trichosporon asahii fungemia and covid 19 co infection an emerging fungal pathogen case report and review of the literature
topic COVID-19
Trichosporon asahii
Fungemia
Voriconazole
Central venous catheters
url http://www.sciencedirect.com/science/article/pii/S2214250921002006
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