Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells

Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells

Vascular smooth muscle cell (VSMC) motility is essential during both physiological and pathological vessel remodeling. Although ageing has emerged as a major risk factor in the development of cardiovascular disease, our understanding of the impact of ageing on VSMC motility remains limited. Prelamin...

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Bibliographic Details
Main Authors: Lauren J. Porter, Mark R. Holt, Daniel Soong, Catherine M. Shanahan, Derek T. Warren
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Cells
Subjects:
prelamin A
migratory persistence
Rac1
Online Access:http://www.mdpi.com/2073-4409/5/4/41

Internet

http://www.mdpi.com/2073-4409/5/4/41

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