Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

Abstract Background Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence. Additionally, replicative cellular sene...

Full description

Bibliographic Details
Main Authors: Yu-Hsiu Chen, Xin Zhang, David Attarian, Virginia Byers Kraus
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Arthritis Research & Therapy
Subjects:
CBX4
Cellular senescence
DPP4
Senomorphic
Osteoarthritis
Online Access:https://doi.org/10.1186/s13075-023-03183-8

Internet

https://doi.org/10.1186/s13075-023-03183-8

Similar Items