Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells

Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells

The present study was designed to evaluate how estradiol alone or in combination with G protein-coupled estrogen receptor (GPER) agonists and GPER and peroxisome proliferator-activated receptor (PPAR) antagonists alter the expression of tumor growth factor β (TGF-β), cyclooxygenase-2 (COX-2), hypoxi...

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Bibliographic Details
Main Authors: Ewelina Gorowska-Wojtowicz, Michal Duliban, Malgorzata Kotula-Balak, Barbara Bilinska
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
testis
Leydig cells
estrogens
G protein-coupled estrogen receptor (GPER)
peroxisome proliferator-activated receptors (PPARs)
GPER agonist/antagonist
Online Access:https://www.mdpi.com/2227-9059/10/6/1390

Internet

https://www.mdpi.com/2227-9059/10/6/1390

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