Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition mechanism of the bile acid cholate to hCA II was provided in 2014 by X-ray crystallography. Herein, we extend the inhibi...

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Bibliographic Details
Main Authors: Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Bruno Cerra, Antimo Gioiello, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
inhibitor
steroids
phenol
bile acid
Online Access:http://dx.doi.org/10.1080/14756366.2018.1512597

Internet

http://dx.doi.org/10.1080/14756366.2018.1512597

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