Non-canonical transcriptional regulation of the poor prognostic factor UGT2B17 in chronic lymphocytic leukemic and normal B cells

Non-canonical transcriptional regulation of the poor prognostic factor UGT2B17 in chronic lymphocytic leukemic and normal B cells

Abstract Background High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism. The key determinants driving expression...

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Bibliographic Details
Main Authors: Michèle Rouleau, Lyne Villeneuve, Eric P. Allain, Jules McCabe-Leroux, Sophie Tremblay, Flora Nguyen Van Long, Ashwini Uchil, Charles Joly-Beauparlant, Arnaud Droit, Chantal Guillemette
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Cancer
Subjects:
Glycosyltransferase
Leukemic B cells
Alternative promoter
STAT3
NF-κB
Interferon regulation factors IRF
Online Access:https://doi.org/10.1186/s12885-024-12143-7

Internet

https://doi.org/10.1186/s12885-024-12143-7

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