Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma
There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13568 |
| _version_ | 1819126235949694976 |
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| author | Xiao-Yan Ming Li Fu Li-Yi Zhang Yan-Ru Qin Ting-Ting Cao Kwok Wah Chan Stephanie Ma Dan Xie Xin-Yuan Guan |
| author_facet | Xiao-Yan Ming Li Fu Li-Yi Zhang Yan-Ru Qin Ting-Ting Cao Kwok Wah Chan Stephanie Ma Dan Xie Xin-Yuan Guan |
| author_sort | Xiao-Yan Ming |
| collection | DOAJ |
| description | There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling. |
| first_indexed | 2024-12-22T07:52:49Z |
| format | Article |
| id | doaj.art-c4e41a7639424cc9a91de517acbe0487 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:52:49Z |
| publishDate | 2016-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c4e41a7639424cc9a91de517acbe04872022-12-21T18:33:27ZengNature PortfolioNature Communications2041-17232016-12-017111410.1038/ncomms13568Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinomaXiao-Yan Ming0Li Fu1Li-Yi Zhang2Yan-Ru Qin3Ting-Ting Cao4Kwok Wah Chan5Stephanie Ma6Dan Xie7Xin-Yuan Guan8Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Pharmacology, Shenzhen Key Laboratory of Translational Medicine of Tumor and Cancer Research Centre, School of Medicine, Shenzhen UniversityDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, The First Affiliated Hospital, Zhengzhou UniversityDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongCentre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong KongCentre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer CenterDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongThere is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.https://doi.org/10.1038/ncomms13568 |
| spellingShingle | Xiao-Yan Ming Li Fu Li-Yi Zhang Yan-Ru Qin Ting-Ting Cao Kwok Wah Chan Stephanie Ma Dan Xie Xin-Yuan Guan Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma Nature Communications |
| title | Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| title_full | Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| title_fullStr | Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| title_full_unstemmed | Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| title_short | Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| title_sort | integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma |
| url | https://doi.org/10.1038/ncomms13568 |
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