Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we examine the dosimetry in beagle dogs and cross-reacti...

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Bibliographic Details
Main Authors: Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina Dadachova
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
IGF2R
osteosarcoma
image-based dosimetry RAPID
<sup>89</sup>Zr
<sup>177</sup>Lu
tissue cross-reactivity
Online Access:https://www.mdpi.com/1424-8247/16/7/979

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https://www.mdpi.com/1424-8247/16/7/979

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