Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology

Abstract Background Genomic alterations in 8 genes are now the targets of FDA-approved therapeutics in non-small cell lung cancer (NSCLC), but their distribution according to genetic ancestry, sex, histology, and smoking is not well established. Methods Using multi-institutional genetic testing data...

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Bibliographic Details
Main Authors: Elio Adib, Amin H. Nassar, Sarah Abou Alaiwi, Stefan Groha, Elie W. Akl, Lynette M. Sholl, Kesi S. Michael, Mark M. Awad, Pasi A. Jӓnne, Alexander Gusev, David J. Kwiatkowski
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Genome Medicine
Subjects:
Non-small cell lung cancer
Targeted therapies
Targetable genomic alterations
Genetic ancestry
Smoking
Online Access:https://doi.org/10.1186/s13073-022-01041-x

Internet

https://doi.org/10.1186/s13073-022-01041-x

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