A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions

A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions

Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative str...

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Bibliographic Details
Main Authors: Mengchen Lu, Xian Zhang, Jing Zhao, Qidong You, Zhengyu Jiang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Keap1-Nrf2 pathway
Protein-protein interaction
H2O2
Prodrug
Inflammation
Oral administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720304948

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http://www.sciencedirect.com/science/article/pii/S2213231720304948

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