Synthesis of Novel Pyrido[1,2-<i>c</i>]pyrimidine Derivatives with 6-Fluoro-3-(4-piperidynyl)-1,2-benzisoxazole Moiety as Potential SSRI and 5-HT<sub>1A</sub> Receptor Ligands

Synthesis of Novel Pyrido[1,2-<i>c</i>]pyrimidine Derivatives with 6-Fluoro-3-(4-piperidynyl)-1,2-benzisoxazole Moiety as Potential SSRI and 5-HT<sub>1A</sub> Receptor Ligands

Two series of novel 4-aryl-2H-pyrido[1,2-c]pyrimidine (6a–i) and 4-aryl-5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine (<b>7a–i</b>) derivatives were synthesized. The chemical structures of the new compounds were confirmed by <sup>1</sup>H and <sup>13</sup>C NMR spectr...

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Bibliographic Details
Main Authors: Marek Król, Grzegorz Ślifirski, Jerzy Kleps, Szymon Ulenberg, Mariusz Belka, Tomasz Bączek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Beata Duszyńska, Franciszek Herold
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
antidepressants
pyrido[1,2-<i>c</i>]pyrimidines
dual 5-HT<sub>1A</sub>/SERT activity
drug design
Online Access:https://www.mdpi.com/1422-0067/22/5/2329

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https://www.mdpi.com/1422-0067/22/5/2329

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