SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening

SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, SARS2) is responsible for the COVID-19 pandemic and infections that continue to affect the lives of millions of people worldwide, especially those who are older and/or immunocompromised. The SARS2 main protease enzyme, Mpro (also called 3C...

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Bibliographic Details
Main Authors: Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Ashley Cuell, Megan Tansiongco, Christina B. Cooley, Yanjun Chen, Agnieszka Dabrowska, Rahul Basu, Paulina Duhita Anindita, Dahai Luo, Peter I. Dosa, Daniel A. Harki, Thomas Bannister, Louis Scampavia, Timothy P. Spicer, Reuben S. Harris
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:SLAS Discovery
Subjects:
Antiviral drugs
cell-based ultra-high throughput screening (uHTS)
protease inhibitors
SARS-CoV-2 main protease (Mpro/3CLpro)
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000431

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http://www.sciencedirect.com/science/article/pii/S2472555224000431

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