Detection of Expression Quantitative Trait Loci in Complex Mouse Crosses: Impact and Alleviation of Data Quality and Complex Population Substructure

Detection of Expression Quantitative Trait Loci in Complex Mouse Crosses: Impact and Alleviation of Data Quality and Complex Population Substructure

Complex Mus Musculus crosses e.g. heterogeneous stock, provide increased resolution for quantitative trait loci detection. However, increased genetic complexity challenges detection methods, with discordant results due to low data quality or complex genetic architecture. We quantified the impact of...

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Bibliographic Details
Main Authors: Ovidiu Dan Iancu, Priscila eDarakjian, Sunita eKawane, Daniel eBottomly, Robert eHitzemann, Shannon K McWeeney
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Genetics
Subjects:
Gene Expression
Collaborative Cross
mouse genetics
eQTL detection
population substructure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00157/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00157/full

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