Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

T cells exhibit heterogeneous functional states, which correlate with responsiveness to immune checkpoint blockade and prognosis of tumor patients. However, the molecular regulatory mechanisms underlying the dynamic process of T cell state transition remain largely unknown. Based on single-cell tran...

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Bibliographic Details
Main Authors: Min Yan, Jing Hu, Huating Yuan, Liwen Xu, Gaoming Liao, Zedong Jiang, Jiali Zhu, Bo Pang, Yanyan Ping, Yunpeng Zhang, Yun Xiao, Xia Li
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
T cell dysfunction
state transition trajectory
dynamic regulatory network
pseudo-times
critical regulators
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002547

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http://www.sciencedirect.com/science/article/pii/S2162253121002547

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