The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion

The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion

MRGPRX2, the human member of the MAS-related G-protein-coupled receptors (GPCRs), mediates the immunoglobulin E (IgE)-independent responses of a subset of mast cells (MCs) that are associated with itch, pain, neurogenic inflammation, and pseudoallergy to drugs. The mechanisms underlying the response...

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Bibliographic Details
Main Authors: Pia Lazki-Hagenbach, Elisabeth Kleeblatt, Mitsunori Fukuda, Hydar Ali, Ronit Sagi-Eisenberg
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
mast cells
MAS-related G-protein-coupled receptors
MRGPRX2
RBL-2H3
Rab GTPase
degranulation
Online Access:https://www.mdpi.com/2073-4409/13/1/93

Internet

https://www.mdpi.com/2073-4409/13/1/93

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