STDP and mental retardation: dysregulation of dendritic excitability in Fragile X syndrome

Development of cognitive function requires the formation and refinement of synaptic networks of neurons in the brain. Morphological abnormalities of synaptic spines occur throughout the brain in a wide variety of syndromic and non-syndromic disorders of mental retardation (MR). In both neurons from...

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Bibliographic Details
Main Authors: Rhiannon M Meredith, Huibert D Mansvelder
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-06-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00010/full