JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

Summary: Janus kinase 2 (valine to phenylalanine at residue 617) (JAK2V617F) mutations lead to myeloproliferative neoplasms associated with elevated myeloid, erythroid, and megakaryocytic cells. Alternatively these same mutations can lead to the condition of clonal hematopoiesis with no impact on bl...

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Bibliographic Details
Main Authors: Soichi Sano, MD, PhD, Ying Wang, MD, PhD, Yoshimitsu Yura, MD, PhD, Miho Sano, MD, PhD, Kosei Oshima, MD, PhD, Yue Yang, PhD, Yasufumi Katanasaka, PhD, Kyung-Duk Min, MD, PhD, Shinobu Matsuura, DVM, PhD, Katya Ravid, DSc, Golam Mohi, PhD, Kenneth Walsh, PhD
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19301834

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http://www.sciencedirect.com/science/article/pii/S2452302X19301834

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