Polyfunctional T cells and unique cytokine clusters imprint the anti rAAV2/rAAV9 vector immune response

Polyfunctional T cells and unique cytokine clusters imprint the anti rAAV2/rAAV9 vector immune response

Polyfunctional T cells programmed to perform activities such as degranulation of lytic enzymes and simultaneous production of multiple cytokines are associated with more effective control of viral infections. Immune responses to recombinant adeno-associated virus (rAAV) vector delivery systems can c...

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Bibliographic Details
Main Authors: Stephan J. Holtkamp, Florian R. Lagoda, Adam Lister, Pradeep Harish, Ulrike Kleymann, Theresa Pesch, Chai Fen Soon, Munir Pirmohamed, Dean Naisbitt, Mark Trautwein
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
adeno-associated virus
immunogenicity
CD4 T cell immunity
gene therapy
polyfunctional T cells
T cell secretome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1450524/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1450524/full

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