RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial

RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial

Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface ant...

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Bibliographic Details
Main Authors: Gemma Moncunill, Stephen C. De Rosa, Aintzane Ayestaran, Augusto J. Nhabomba, Maximillian Mpina, Kristen W. Cohen, Chenjerai Jairoce, Tobias Rutishauser, Joseph J. Campo, Jaroslaw Harezlak, Héctor Sanz, Núria Díez-Padrisa, Nana Aba Williams, Daryl Morris, John J. Aponte, Clarissa Valim, Claudia Daubenberger, Carlota Dobaño, M. Juliana McElrath
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium falciparum
vaccine
cellular immune responses
T cells
intracellular cytokine staining
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01008/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01008/full

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