A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss

Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults with mild-moderate sensorineural hearing los...

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Bibliographic Details
Main Authors: Anne G. M. Schilder, Stephan Wolpert, Shakeel Saeed, Leonie M. Middelink, Albert S. B. Edge, Helen Blackshaw, REGAIN Consortium, Kostas Pastiadis, Athanasios G. Bibas
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45784-0

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https://doi.org/10.1038/s41467-024-45784-0

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