Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt
Objectives: This study was conducted to determine breast cancer survival time and the association between breast cancer survival and socio-demographic and pathologic factors among women, in El-Minia, Egypt. While there has been much researches regarding prognostic factors for breast cancer but the m...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
Series: | International Journal of Preventive Medicine |
Subjects: | |
Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2011;volume=2;issue=3;spage=131;epage=138;aulast=Seedhom |
_version_ | 1819243462815383552 |
---|---|
author | Amany Edward Seedhom Nashwa Nabil Kamal |
author_facet | Amany Edward Seedhom Nashwa Nabil Kamal |
author_sort | Amany Edward Seedhom |
collection | DOAJ |
description | Objectives: This study was conducted to determine breast cancer survival time and the association between breast cancer survival and socio-demographic and pathologic factors among women, in El-Minia, Egypt. While there has been much researches regarding prognostic factors for breast cancer but the majority of these studies were from developed countries. El-Minia has a population of approximately 4 million. To date, no research has been performed to determine breast cancer survival and the factors affecting it in El-minia.
Methods : This retrospective study used data obtained from the cancer registry in the National Institute of Oncology in El-Minia and included 1207 women diagnosed with first primary breast cancer between 1 st January 2005 and 31st December 2009 and followed to 30 th June 2010. The association between survival and sociodemographic and pathological factors and distant metastasis at diagnosis, and treatment options was investigated using unifactorial chi-square test and multi-factorial (Cox regression) analyses. Kaplan-Meier analysis was used to compare survival time among different groups.
Results: Median survival time was 83.8 ± 3.2. Cox regression showed that high vs low educational level (Hazard ratio (HR)= 0.35, 95% CI; 0.27-0.46), metastases to bone (HR = 3.22, 95% CI: 1.71-6.05), metastases to lung (HR= 2.314, 95% CI: 1.225-4.373), tumor size (≤ 2 cm vs ≥ 5 cm: HR = 1.4, 95% CI: 1.1-1.8) and number of involved nodes (1 vs > 10 HR = 5.21, 95%CI: 3.1-9.01) were significantly related to survival.
Conclusions: The results showed the need to develop screening programs and standardized treatment regimens in a tax-funded health care system. |
first_indexed | 2024-12-23T14:56:05Z |
format | Article |
id | doaj.art-c50817cd0ba04ac48dcc27066de63d92 |
institution | Directory Open Access Journal |
issn | 2008-7802 2008-8213 |
language | English |
last_indexed | 2024-12-23T14:56:05Z |
publishDate | 2011-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | International Journal of Preventive Medicine |
spelling | doaj.art-c50817cd0ba04ac48dcc27066de63d922022-12-21T17:42:46ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132011-01-0123131138Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, EgyptAmany Edward SeedhomNashwa Nabil KamalObjectives: This study was conducted to determine breast cancer survival time and the association between breast cancer survival and socio-demographic and pathologic factors among women, in El-Minia, Egypt. While there has been much researches regarding prognostic factors for breast cancer but the majority of these studies were from developed countries. El-Minia has a population of approximately 4 million. To date, no research has been performed to determine breast cancer survival and the factors affecting it in El-minia. Methods : This retrospective study used data obtained from the cancer registry in the National Institute of Oncology in El-Minia and included 1207 women diagnosed with first primary breast cancer between 1 st January 2005 and 31st December 2009 and followed to 30 th June 2010. The association between survival and sociodemographic and pathological factors and distant metastasis at diagnosis, and treatment options was investigated using unifactorial chi-square test and multi-factorial (Cox regression) analyses. Kaplan-Meier analysis was used to compare survival time among different groups. Results: Median survival time was 83.8 ± 3.2. Cox regression showed that high vs low educational level (Hazard ratio (HR)= 0.35, 95% CI; 0.27-0.46), metastases to bone (HR = 3.22, 95% CI: 1.71-6.05), metastases to lung (HR= 2.314, 95% CI: 1.225-4.373), tumor size (≤ 2 cm vs ≥ 5 cm: HR = 1.4, 95% CI: 1.1-1.8) and number of involved nodes (1 vs > 10 HR = 5.21, 95%CI: 3.1-9.01) were significantly related to survival. Conclusions: The results showed the need to develop screening programs and standardized treatment regimens in a tax-funded health care system.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2011;volume=2;issue=3;spage=131;epage=138;aulast=SeedhomBreast cancerSurvivalEgypt |
spellingShingle | Amany Edward Seedhom Nashwa Nabil Kamal Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt International Journal of Preventive Medicine Breast cancer Survival Egypt |
title | Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt |
title_full | Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt |
title_fullStr | Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt |
title_full_unstemmed | Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt |
title_short | Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt |
title_sort | factors affecting survival of women diagnosed with breast cancer in el minia governorate egypt |
topic | Breast cancer Survival Egypt |
url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2011;volume=2;issue=3;spage=131;epage=138;aulast=Seedhom |
work_keys_str_mv | AT amanyedwardseedhom factorsaffectingsurvivalofwomendiagnosedwithbreastcancerinelminiagovernorateegypt AT nashwanabilkamal factorsaffectingsurvivalofwomendiagnosedwithbreastcancerinelminiagovernorateegypt |